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尿酸降了為什么關節反而更痛
2020-01-11 18:43   来源:  www.eoto-online.com   评论:0 点击:

尿酸降了為什么關節反而更痛????????不少人都患有高尿酸血症,用药后尿酸降下来了,关节疼痛的症状却没好转

????????不少人都患有高尿酸血症,用药后尿酸降下来了,关节疼痛的症状却没好转反而加重了,你知道这是为什么吗?记者请来南方医科大学第三附属医院风湿免疫科主任孙尔维教授来为大家讲一讲。

? ?? ?? ?? Many people are suffering from hyperuricemia, after the use of uric acid down, the symptoms of joint pain has not improved but aggravated, do you know why this is? The reporter invited Professor Sun Erwei of the Department of Rheumatology and Immunology of the Third Affiliated Hospital of Southern Medical University to speak for you.

????????大家都知道,痛风的病因非常明确,就是体内尿酸过高超出人体可承受范围而形成结晶,沉积在关节、皮肤、血管等部位,刺激到体内负责清理垃圾消灭细菌的巨噬细胞和中性粒细胞,释放出导致人体组织肿胀发红、发热发痛的细小分子,也就是发生了炎症反应。但是尿酸结晶并不是细菌,巨噬细胞和中性粒细胞对这种炎症是无能为力的,它们只能越帮越忙,导致炎症加重。所以痛风患者在急性发作期那是相当痛的。

? ?? ?? ?? As we all know, the cause of gout is very clear, that is, the body uric acid is too high beyond the human body can afford to form crystallization, deposited in the joints, skin, blood vessels and other parts of the body, stimulate the body to clean up the bacterial macrophages and neutrophils, release the body tissue swelling red, fever pain small molecules, that is, an inflammatory reaction. But uric acid crystallization is not bacteria, macrophages and neutrophils are powerless to this inflammation, they can only help more and more, leading to inflammation aggravated. So gout patients in the acute attack period that is quite painful.

????????体内要自行清除尿酸,还得靠肾脏。但肾脏的运动能力也有限,它只能清除血液里的尿酸,对于组织、肌肉、血管,尤其是关节沉积的尿酸一样是鞭长莫及的。大量尿酸在体内长期积累,要回到血液循环中去,再由肾脏清除,是一个漫长的过程。过量的尿酸没有及时清除,就会在组织中形成结晶盐。

? ?? ?? ?? To get rid of uric acid, the body has to rely on its kidneys. But the kidney's ability to exercise is limited, and it removes only uric acid from the blood, which is as long as the uric acid deposited in tissues, muscles, blood vessels and, in particular, joints. A large amount of uric acid accumulates in the body for a long time, to go back to the blood circulation, and then removed by the kidney, is a long process. Too much uric acid is not removed in time to form crystalline salts in the tissue.

????????症状比较轻时,身体会自行抵抗,启动抗炎症反应,这样一来急性发作关节痛几天后可以自行缓解,但尿酸过多的问题没有解决,一有风吹草动,疼痛就又来袭。如果痛时才吃药,好了伤疤又忘了痛,继续喝酒吃肉,痛风就会越来越频繁发作、关节一次比一次更痛。

? ?? ?? ?? When the symptoms are mild, the body resists itself and initiates an anti-inflammatory response, which allows it to relieve itself after a few days, but the problem of excessive uric acid has not been solved. If you take your medicine when it hurts, forget it when you're scarred, and continue to drink and eat meat, gout becomes more frequent and joints become more painful each time.

????????所以说,痛风只是表面现象,体内尿酸过高才是疾病的根本原因。止痛是必须的,但只有把尿酸降至正常水平,才能根本上避免痛风的发生。

? ?? ?? ?? Therefore, gout is only a superficial phenomenon, and high uric acid in the body is the root cause of the disease. Pain relief is necessary, but only by reducing uric acid to normal levels can gout be fundamentally avoided.

????????既然如此,为什么临床上那么多“痛友”,把尿酸降下来,关节疼痛没有缓解反而更甚了呢?孙尔维说,关键问题在于,尿酸并不是降得越快越好。

? ?? ?? ?? In this case, why so many clinical \"pain friends \", uric acid down, joint pain has not been relieved but even more? The key problem, says mr sun, is that uric acid doesn't fall as fast as possible.

????????通常来说,药物是通过血液发生作用的。对于长期高尿酸血症的患者来说,血液中的尿酸降低了,肌肉、皮肤、血管、器官、骨骼等全身各组织中沉积的大量尿酸,就会向血液转移,很容易打破关节中尿素的浓度平衡,从而使得结晶更容易产生,从而诱发急性痛风的发作,导致疼痛难忍。

? ?? ?? ?? In general, drugs work through the blood. For patients with long-term hyperuricemia, when the uric acid in the blood is reduced, the large amount of uric acid deposited in the whole body tissues, such as muscles, skin, blood vessels, organs, bones and so on, will be transferred to the blood, and it is easy to break the balance of urea concentration in the joint, thus making the crystallization more easy to produce, thus inducing the attack of acute gout, resulting in pain is difficult to bear.

????????怎样静悄悄地把尿酸降于无形之中,不打破平衡,几乎也是一种艺术。所以并不是痛的时候自己吃点消炎药,再吃点降酸药就可以了。一切还是得听医生指挥。

? ?? ?? ?? How to quietly reduce uric acid to the invisible without breaking the balance is almost an art. So it's not painful when you take some anti-inflammatory drugs, and then take some acid medicine can be. It's still under the doctor's command.

????????孙尔维提醒说,并不是所有血尿酸升高的人都会出现关节痛的症状。有很多人多次检查都发现血尿酸超标,甚至越来越高,医学上称为高尿酸血症。100名高尿酸血症患者当中,大约只有10个患者会出现痛风。很多人因为没有出现痛风就不把升高的血尿酸当一回事,不去治疗也不控制饮食。

? ?? ?? ?? Not all people with elevated blood uric acid have symptoms of joint pain, Sun cautioned. Many people have found that blood uric acid exceeds the standard, even higher and higher, medically known as hyperuricemia. Of the 100 patients with hyperuricemia, only about 10 have gout. Many people don't take elevated blood uric acid seriously because they don't have gout, don't treat it and don't control their diet.

????????但尿酸毕竟是一种代谢废物,如果长期过量沉积在肾脏,在这里形成结晶甚至结石,就会导致肾脏功能受损,影响身体其他代谢物排出体外。

? ?? ?? ?? But after all, uric acid is a metabolic waste that, if deposited in the kidney for a long period of time, crystals or even stones form here, which can lead to impaired kidney function and affect the excretion of other metabolites in the body.

????????高尿酸还可能破坏胰岛细胞功能,诱发糖尿病;同时也是发生高血压、冠心病、心梗、脑梗等心血管事件的高危因素。换句话说,尿酸结晶沉积在关节,造成关节肿痛,还可能沉积在身体的其他器官,静悄悄地造成更大伤害,只不过早期可能没有明显不适症状而已。所以如果开始关节痛了,反而是身体发出了警示,提醒你注意过量尿酸已经开始破坏关节,可能需要进一步检查其他器官是否受到波及,要在专科医生的指导下进行规范的降尿酸治疗。(全媒体记者周洁莹通讯员游华玲)

? ?? ?? ?? High uric acid may also destroy islet cell function and induce diabetes. It is also a high risk factor for cardiovascular events such as hypertension, coronary heart disease, myocardial infarction and cerebral infarction. In other words, uric acid crystals deposit in joints, causing joint swelling and pain, and may also deposit in other organs of the body, quietly causing more damage, except that there may be no obvious symptoms of discomfort in the early stages. So if you start having joint pain, it's the body that warns you that excessive uric acid has begun to destroy the joints, and that you may need to check further to see if other organs are affected by it. (Media Reporter Zhou Jieying Correspondent Yu Hualing)


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